HCID 22885052, compound → HCID 22885046, compound

HRID 1599932Notes

Reaction equation

HRID 1599932 reaction equation
[C:1]([NH:8][C@@H:9]([CH3:28])[CH2:10][O:11][C:12]1[CH:27]=[CH:26][C:15]([C:16]([O:18]CC2C=CC=CC=2)=[O:17])=[CH:14][CH:13]=1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]>[Pd].C(O)C>[C:1]([NH:8][C@@H:9]([CH3:28])[CH2:10][O:11][C:12]1[CH:27]=[CH:26][C:15]([C:16]([OH:18])=[O:17])=[CH:14][CH:13]=1)([O:3][C:4]([CH3:6])([CH3:7])[CH3:5])=[O:2]

Participants

4

Reactant 1

HCID 22885052HCID 22885052, compound

Product 1

HCID 22885046HCID 22885046, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of 22-3 (1.6 g, 4.3 mmol), 10% Pd/C (0.33 g) and ethanol (25 mL) was stirred under a hydrogen atmosphere (1 arm) for 20 h. Filtration through a celite pad followed by concentration of the filtrate gave 22-4 as a colorless solid.

Workup

  1. filtrationFiltration through a celite pad

Sources & evidence

ORD record
ord-bcb193774a7e435a80d059dde0a89a81
Source dataset
uspto-grants-1998_04
Patent number
US05741796

Reaction notes

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