化工社化工社 化学情報印刷レポート · 研究参考用
Triethylamine → Ethyl 4-(2-aminopyridin-6-ylethynyl)benzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 2-Amino-6-bromopyridine | HCID 300809 | — |
| 反応物 | Ethyl 4-ethynylbenzoate | HCID 15540683 | — |
| 触媒 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 触媒 | HCID 178418476 | HCID 178418476 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | Ethyl 4-(2-aminopyridin-6-ylethynyl)benzoate | HCID 10683170 | — |
反応手順
2-Amino-6-bromopyridine (0.38 g, 2.4 mmol), alkyne 29-2 (0.35 g, 2.0 mmol), Et3N (1.0 mL, 7.2 mmol), (Ph3P)2PdCl2 (76 mg, 0.11 mmol), an CuI (26 mg, 0.14 mmol) were combined in 5 mL CH3CN, sealed in a glass pressure tube and heated to 100° for 3 h. The mixture was diluted with EtOAc, washed with water and brine, dried (MgSO4), concentrated, and purified by flash chromatography (silica, 5% acetone/hexane), to give 29-3 as a tan solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05741796 |
| 出典データセット | uspto-grants-1998_04 |
| ORD ID | ord-e80a1f5dd4c944258e69281d2f45d4f9 |
| 出典メモ | uspto-grants-1998_04 |