HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium methanethiolate → Ethyl 2-(methylthio)-4-(trifluoromethyl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium methanethiolate | HCID 4378561 | — |
| Reactant | HCID 11780008 | HCID 11780008 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Ethyl 2-(methylthio)-4-(trifluoromethyl)benzoate | HCID 11010829 | 94.6% |
Reaction Steps
Example 3 is repeated except that 2.53 g (10 mmol) of ethyl 2-chloro-4-(trifluoromethyl)benzoate are reacted with 0.77 g (11 mmol) of sodium thiomethoxide in 15 ml of DMF. 2.5 g of ethyl 2-methylmercapto-4-(trifluoromethyl)benzoate of high purity are obtained. It is therefore not necessary to purify by distillation.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05744021 |
| Source dataset | uspto-grants-1998_04 |
| ORD ID | ord-d2e0628730b241a68f33f91d08c5431b |
| Source note | uspto-grants-1998_04 |