Estradiol → Diethylstilbestrol

HRID 1599967Notes

Reaction equation

HRID 1599967 reaction equation
[CH3:1][C@@:2]12[C@@H:18]([OH:19])[CH2:17][CH2:16][C@H:15]1[C@H:14]1[C@@H:5]([C:6]3[CH:7]=[CH:8][C:9]([OH:20])=[CH:10][C:11]=3[CH2:12][CH2:13]1)[CH2:4][CH2:3]2.CN(NC1SC=C(C2OC([N+]([O-])=O)=CC=2)N=1)C>>[CH3:3][CH2:4]/[C:5](=[C:14](/[CH2:13][CH3:12])\[C:15]1[CH:16]=[CH:17][C:18]([OH:19])=[CH:1][CH:2]=1)/[C:6]1[CH:7]=[CH:8][C:9]([OH:20])=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 5757Estradiol2×HCID 922482-(2,2-Dimethylhydrazino)-4-(5-nitro-2-furyl)thiazole

Product 1

HCID 448537Diethylstilbestrol

Procedure

[6,73H] estradiol (40-60) Ci/mmol) ([3H]E2), 7α, 17 α-dimethyl [17α-methyl 3H]-19-nortestosterone (70-85 Ci/mmol) ([3H] DMNT) 16 α-ethyl-21-hydroxy-19-nor [6,73 H]-pregn-4-ene-3,20-dione (40-60 Ci/mmol) (3H! ORG 2058), [3 H]-triamcinolone acetonide (20-40 Ci/mmol) (3H!TA), unlabeled DMNT, and ORG 2058 were obtained from Amersham, Arlington Heights, Ill. Unlabeled TA was obtained from Sigma Chemical Co., St. Louis, Mo., unlabeled diethylstilbestrol (DES) and E2 were obtained from Steroids, Wilton, N.H. All other chemicals were reagent grade and were obtained from commercial sources.

Sources & evidence

ORD record
ord-f0a4425449b14b1cbb2f9bbd72a9c41e
Source dataset
uspto-grants-1998_04
Patent number
US05744356

Reaction notes

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