Sulfuryl chloride → HCID 15220185, compound

HRID 1599983Notes

Reaction equation

HRID 1599983 reaction equation
S(Cl)([Cl:4])(=O)=O.[Cl:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:17]=[C:16]([O:18][CH:19]([F:21])[F:20])[N:15]([CH3:22])[N:14]=2)=[CH:9][CH:8]=1>C(Cl)(Cl)(Cl)Cl>[Cl:4][C:17]1[C:13]([C:10]2[CH:9]=[CH:8][C:7]([Cl:6])=[CH:12][CH:11]=2)=[N:14][N:15]([CH3:22])[C:16]=1[O:18][CH:19]([F:21])[F:20]

Participants

4

Reactant 2

HCID 24648Sulfuryl chlorideHCID 15220184HCID 15220184, compound

Product 1

HCID 15220185HCID 15220185, compound

Reagents, catalysts & solvents 1

HCID 5943Carbon TetrachlorideSolvent2×

Procedure

A solution of 74.0 g (0,549 mol) of sulfuryl chloride in 200 ml of carbon tetrachloride was added slowly to a solution of 128.9 g (0.5 mol) of 3-(4-chlorophenyl)-5-difluoromethoxy-1-methyl-1H-pyrazole in 500 ml of carbon tetrachloride. After the exothermic reaction with evolution of gas had subsided, the reaction mixture was stirred at 20°-25° C.for 2 hours more. The reaction solution was then washed with water, saturated sodium hydrogen carbonate solution and saturated sodium chloridesolution, and finally dried and concentrated. Yield: 139.3 g; 1H-NMR (270 MHz, in CDCl3): δ [ppm]=7,79 (d,2H), 7,43 (d,2H), 6,70 (t,1H), 3,85 (s,3H).

Workup

  1. customAfter the exothermic reaction with evolution of gas
  2. washThe reaction solution was then washed with water, saturated sodium hydrogen carbonate solution and saturated sodium chloridesolution
  3. customfinally dried
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-e4813aab34134dc1920ec1beeee0164b
Source dataset
uspto-grants-1998_04
Patent number
US05744426

Reaction notes

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