Sulfuric Acid → 4-Chloro-3-(4-chloro-3-formylphenyl)-5-difluoromethoxy-1-methyl-1H-pyrazole

HRID 1599985Notes

Reaction equation

HRID 1599985 reaction equation
Br[CH:2](Br)[C:3]1[CH:4]=[C:5]([C:10]2[C:14]([Cl:15])=[C:13]([O:16][CH:17]([F:19])[F:18])[N:12]([CH3:20])[N:11]=2)[CH:6]=[CH:7][C:8]=1[Cl:9].S(=O)(=O)(O)[OH:23]>>[Cl:15][C:14]1[C:10]([C:5]2[CH:6]=[CH:7][C:8]([Cl:9])=[C:3]([CH:2]=[O:23])[CH:4]=2)=[N:11][N:12]([CH3:20])[C:13]=1[O:16][CH:17]([F:19])[F:18]

Participants

3

Reactant 2

HCID 1118Sulfuric AcidHCID 15220188HCID 15220188, compound

Product 1

HCID 152201894-Chloro-3-(4-chloro-3-formylphenyl)-5-difluoromethoxy-1-methyl-1H-pyrazole

Conditions

Temperature
100 °C

Procedure

At 85° C., 4.65 g (10 mmol) of 3-(3-dibromomethyl-4-chloro-phenyl)-4-chloro-5-difluoromethoxy-1-methyl-1H-pyrazole were introduced a little at a time into 7 ml of concentrated sulfuric acid. The reaction solution was then stirred at 100° C. for 5 minutes, then stirred into 40 ml of ice-water. The solid product formed was filtered off and dried. Yield: 3.0 g;

Workup

  1. customThe solid product formed
  2. filtrationwas filtered off
  3. customdried

Sources & evidence

ORD record
ord-61280ebf06254cbf9a598d30f0ce8bd4
Source dataset
uspto-grants-1998_04
Patent number
US05744426

Reaction notes

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