HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 15283247, compound → 7,9-Difluoro-1-methyl-8-(2-methylamino-8-azabicyclo[4.3.0]non-3-en-8-yl)-5-oxo-5H-thiazolo[3.2-a]quinoline-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 15283247 | HCID 15283247 | — |
| Reactant | 7,8,9-trifluoro-1-methyl-5-oxo-5H-thiazolo[3,2-a]quinoline-4-carboxylic acid | HCID 15342002 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 7,9-Difluoro-1-methyl-8-(2-methylamino-8-azabicyclo[4.3.0]non-3-en-8-yl)-5-oxo-5H-thiazolo[3.2-a]quinoline-4-carboxylic acid | HCID 15342003 | — |
Reaction Steps
100 mg (0.318 mmol) of 7,8,9-trifluoro-1-methyl-5-oxo-5H-thiazolo[3,2-a]quinoline-4-carboxylic acid are heated at 80° C. under argon for 2 hours with 97 mg (0.64 mmol) of 2-methylamino-8-azabicyclo[4.3.0]-non-3-ene in 3 ml of DMSO. The mixture is concentrated in a high vacuum, the residue is recrystallized from ethanol and the product is dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05744478 |
| Source dataset | uspto-grants-1998_04 |
| ORD ID | ord-35016ce939bd4246a83c0c352e4e0cd6 |
| Source note | uspto-grants-1998_04 |