Thiourea → HCID 21699321, compound

HRID 1600004Notes

Reaction equation

HRID 1600004 reaction equation
[NH2:1][C:2]([NH2:4])=[S:3].[Cl:5][C:6]1[C:7](=[O:15])[NH:8][C:9](=[O:14])[NH:10][C:11]=1[CH2:12]Cl>C(O)C>[ClH:5].[Cl:5][C:6]1[C:7](=[O:15])[NH:8][C:9](=[O:14])[NH:10][C:11]=1[CH2:12][S:3][C:2](=[NH:4])[NH2:1]

Participants

4

Reactant 2

HCID 2723790ThioureaHCID 41710565-Chloro-6-(chloromethyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione

Product 1

HCID 21699321HCID 21699321, compoundYield 161.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 140 mg of thiourea in ethanol (3 ml), 300 mg of 5-chloro-6-chloromethyluracil were added, followed by heating for 6 hours under reflux. After the reaction mixture was allowed to cool down, a crystallized matter was collected by filtration, whereby 337 mg of the title compound were obtained (yield: 81%).

Workup

  1. temperatureby heating for 6 hours
  2. temperatureunder reflux
  3. temperatureto cool down
  4. filtrationa crystallized matter was collected by filtration

Sources & evidence

ORD record
ord-ad7ed1497fbb4fcc95f6bca901ab5dbe
Source dataset
uspto-grants-1998_04
Patent number
US05744475

Reaction notes

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