Potassium Hydroxide → HCID 178479424, compound

HRID 1600005Notes

Reaction equation

HRID 1600005 reaction equation
S(O)(O)(=O)=O.CS[C:8](=[NH:10])[NH2:9].[OH-].[K+].[NH2:13][CH2:14][C:15]1[NH:20][C:19](=[O:21])[NH:18][C:17](=[O:22])[C:16]=1[Cl:23]>>[ClH:23].[Cl:23][C:16]1[C:17](=[O:22])[NH:18][C:19](=[O:21])[NH:20][C:15]=1[CH2:14][NH:13][C:8]([NH2:10])=[NH:9]

Participants

4

Reactant 3

HCID 14797Potassium HydroxideHCID 752702-Methyl-2-thiopseudourea sulfateHCID 21699302HCID 21699302, compound

Product 1

HCID 178479424HCID 178479424, compoundYield 66.1%

Conditions

Temperature
80 °C

Procedure

Subsequent to addition of 455 mg of 2-methyl-isothiourea sulfate to 33 ml of a 0.1N aqueous solution of potassium hydroxide under ice cooling, 600 mg of the 6-aminomethyl-5-chlorouracil obtained in Example 22 were added, followed by heating for 2 hours at 80° C. under stirring. After thereaction mixture was allowed to cool down, a crystallized matter was collected by filtration and washed with 2N hydrochloric acid, whereby 287 mg of the title compound were obtained (yield: 33%).

Workup

  1. temperatureto cool down
  2. filtrationa crystallized matter was collected by filtration
  3. washwashed with 2N hydrochloric acid

Sources & evidence

ORD record
ord-5b1f60ea2dc64041a56ec2929958e64d
Source dataset
uspto-grants-1998_04
Patent number
US05744475

Reaction notes

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