Bromine → HCID 9860327, compound

Participants

Reaction Steps

To a solution of 1.0 g of the 6-(1-pyrrolidinyl-methyl)uracil, which had been obtained in Referential Example 7, in acetic acid (10 ml), 1.0 g of bromine was added dropwise, followed by stirring at room temperature for 20 hours. A crystallized matter was collected by filtration and then washed with methanol, whereby 560 mg of the title compound were obtained (yield: 40%). The melting point and NMR spectrum of the thus-obtained compound were in full conformity with those of Compound 2 synthesized by Process A in Example 2.

Provenance & Evidence