HCID 17817992, compound → HCID 15838413, compound

HRID 1600025Notes

Reaction equation

HRID 1600025 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]#[C:8][CH2:9][CH:10]([OH:20])[CH2:11][C:12]#[C:13][C:14]2[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=2)[CH:2]=1>C(O)C.CO.[Pt]=O>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][CH2:8][CH2:9][CH:10]([OH:20])[CH2:11][CH2:12][CH2:13][C:14]2[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=2)[CH:2]=1

Participants

5

Reactant 1

HCID 17817992HCID 17817992, compound

Product 1

HCID 15838413HCID 15838413, compoundYield 98.9%

Reagents, catalysts & solvents 3

HCID 82844Platinum oxide (PtO)CatalystHCID 702EthanolSolventHCID 887MethanolSolvent

Procedure

A suspension of platinum oxide (280 mg) in absolute ethanol (1 mL) was diluted with absolute methanol (10 mL) followed by the addition of compound 1 (2.81 g, 10.73 mmol). The suspension was placed under 40 psi ofhydrogen gas. After hydrogen consumption ceased, the hydrogen was replaced with nitrogen and the reaction was filtered and concentrated to provide 2.87 g of compound 2 as a viscous oil.

Workup

  1. customAfter hydrogen consumption
  2. filtrationthe reaction was filtered
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-1c4b76c9ad5043dab1983c4bce2a98b0
Source dataset
uspto-grants-1998_04
Patent number
US05744485

Reaction notes

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