Water → HCID 86752472, compound

Participants

Reaction Steps

To a solution of the compound (0.94 g, 2 mmol) obtained in the item (c) of Example 1 in ethanol (15 ml), a solution of sodium carbonate (0.17 g, 1.6 mmol) in water (3 ml) and hydroxyamine hydrochloride (0.22 g, 3.2 mmol) are added. After the reaction mixture is heated at reflux for 8 hours, thesolvent is evaporated and the resulting residue is purified with silica gelcolumn chromatography (chloroform-methanol) to give 0.84 g of the titled compound (84%).

Provenance & Evidence