Phosgene → HCID 18923957, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 1.752 g of DL-2-aminopimelic acid, 55 ml of tetrahydrofuranand 16 ml of 1.93M phosgene in toluene is heated, in an oil bath, at 50° C. for 1 hour. Argon is bubbled through the reaction to remove the excess phosgene and the solvents are removed under house vacuum. The resulting oil is dissolved in 14 ml of ethyl alcohol, diluted with 14 ml of petroleum ether and the solution stored overnight at room temperature. The formed crystals are collected and dried to give 1.6 g of the desired product.

Provenance & Evidence