HuagongsheHuagongshe Chemistry Print Report · For research reference only
Deuterium Oxide → 3-[[5-[(Acetylhydroxyamino)methyl]tetrahydro-3-furanyl]thio]-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]-hept-2-ene-2-carboxylic acid monosodium salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Deuterium Oxide | HCID 24602 | — |
| Reactant | 3-[[5-[[Acetyl(phenylmethoxy)amino]methyl]tetrahydro-3-furanyl]thio]-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid monosodium salt | HCID 131719843 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | 3-[[5-[(Acetylhydroxyamino)methyl]tetrahydro-3-furanyl]thio]-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]-hept-2-ene-2-carboxylic acid monosodium salt | HCID 131719845 | 84.9% |
Reaction Steps
A mixture of 0.010 g of product from Example 75, 0.014 g of 10% palladium/carbon, and 1 ml of deuterium oxide is reduced in a Parr apparatus for 2 hours at 30 psi. The reaction solution is filtered and lyophilyzed to give 0.007 g of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05744465 |
| Source dataset | uspto-grants-1998_04 |
| ORD ID | ord-4ca7124b70094c0f9a90a6f99f0d391e |
| Source note | uspto-grants-1998_04 |