Ethylamine → HCID 86752480, compound

HRID 1600119Notes

Reaction equation

HRID 1600119 reaction equation
I[CH2:2][C@@H:3]1[O:7][CH2:6][C@@H:5]([OH:8])[CH2:4]1.[CH2:9]([NH2:11])[CH3:10]>>[CH2:9]([NH:11][CH2:2][C@@H:3]1[O:7][CH2:6][C@@H:5]([OH:8])[CH2:4]1)[CH3:10]

Participants

3

Reactant 2

HCID 6341EthylamineHCID 67649805HCID 67649805, compound

Product 1

HCID 86752480HCID 86752480, compound

Procedure

A solution of 4.0 g of product from Example 121, Isomer B, and 20 ml of 70%aqueous ethylamine is stirred at room temperature, in a pressure bottle, for 60 hours. The reaction is concentrated in vacuo and the residue purified by chromatography (silica gel: 30% methyl alcohol/chloroform) to give 3.2 g of the desired product.

Workup

  1. concentrationThe reaction is concentrated in vacuo
  2. customthe residue purified by chromatography (silica gel: 30% methyl alcohol/chloroform)

Sources & evidence

ORD record
ord-a96e23b31e0247b3a1532a967e1dc03a
Source dataset
uspto-grants-1998_04
Patent number
US05744465

Reaction notes

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