反应详情

To a room temperature solution, under argon, of 10.9 g of product from Example 322 in 115 ml of absolute ethyl alcohol is added 1.57 g of sodium borohydride. The reaction is stirred at room temperature for 1 hour. Wateris added dropwise with stirring and the mixture is concentrated in vacuo. The residue is extracted with methylene chloride, washed with water, driedand concentrated in vacuo to give after chromatography (Silica gel: 50-75% ethyl acetate/hexane) 7.68 g of the desired product.

1. additionWateris added dropwise
2. stirringwith stirring
3. concentrationthe mixture is concentrated in vacuo
4. extractionThe residue is extracted with methylene chloride
5. washwashed with water
6. concentrationconcentrated in vacuo