3-(Chloromethyl)pyridine → HCID 18926590, compound

Participants

Reaction Steps

Treatment of 4-bromo-1H-indole (J.Org.Chem., 48 2066(1983)) (16.95 g) with methyl magnesium bromide (34.6 ml of 3M solution in ether) followed by a dichloromethane solution of 3-(chloromethyl)pyridine (prepared from 17.02 g of 3-(chloromethyl)pyridine hydrochloride) according to the method of Preparation 6 gave the title compound (7.80 g), m.p. 173°-174° C. Found: C,58.90; H,3.88; N,9.80. C,14 H11BrN2 requires: C,58.55; H,3.86; N,9.76%.

Provenance & Evidence