HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → Benzyl (E)-3-[3-(dimethylaminomethyl)-2-methyl-1H-indol-4-yl]-2-propenoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Benzyl (E)-3-(2-methyl-1H-indol-4-yl)-2-propenoate | HCID 86752481 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Benzyl (E)-3-[3-(dimethylaminomethyl)-2-methyl-1H-indol-4-yl]-2-propenoate | HCID 86752485 | — |
Reaction Steps
Treatment of benzyl (E)-3-(2-methyl-1H-indol-4-yl)-2-propenoate (6.20 g) with dimethylamine (3.2 ml of 33% solution in methylated spirit), and formaldehyde (1.68 ml of 40% aqueous solution) in acetic acid (13 ml) and tetrahydrofuran (15 ml) according to the method of Preparation 12 gave thetitle compound as a foam (7.45 g), Rf. 0.3(SS3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05744488 |
| Source dataset | uspto-grants-1998_04 |
| ORD ID | ord-65d75357146440138172a093e1076941 |
| Source note | uspto-grants-1998_04 |