HCID 86752487, compound → HCID 18926584, compound

HRID 1600184Notes

Reaction equation

HRID 1600184 reaction equation
[N:1]1([CH2:6][C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][C:14]=3/[CH:16]=[CH:17]/[C:18]([O:20]CC3C=CC=CC=3)=[O:19])[N:9]([CH2:28][CH2:29][C:30]([O:32][CH3:33])=[O:31])[C:8]=2[CH3:34])[CH:5]=[CH:4][N:3]=[CH:2]1>[Pd]>[C:18]([CH2:17][CH2:16][C:14]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:15]=1[C:7]([CH2:6][N:1]1[CH:5]=[CH:4][N:3]=[CH:2]1)=[C:8]([CH3:34])[N:9]2[CH2:28][CH2:29][C:30]([O:32][CH3:33])=[O:31])([OH:20])=[O:19]

Participants

3

Reactant 1

HCID 86752487HCID 86752487, compound

Product 1

HCID 18926584HCID 18926584, compoundYield 72.5%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Hydrogenation of benzyl (E)-3-[3-(1H-imidazol-1-ylmethyl)-1-(2-methoxycarbonylethyl)-2-methyl-1H-indol-4-yl]-2-propenoate (1.40 g) in the presence of 10% palladium on carbon(0.15 g) according to the method of Preparation 21 gave the title compound (0.82 g), m.p. 136°-138° C.

Sources & evidence

ORD record
ord-3fcb3b882cbc4c60b7c9e38fbfa87fba
Source dataset
uspto-grants-1998_04
Patent number
US05744488

Reaction notes

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