tert-Butanol → HCID 18926523, compound

Participants

Reaction Steps

Treatment of methyl 4-(2-carboxyethyl)-2-methyl-3-(3-pyridylmethyl)-1H-indole-1-propanoate (3.70 g) with diphenylphosphoryl azide (2.95 g), triethylamine (1.08 g), and t-butanol (30 ml) as described in Preparation 29 gave the title compound as an oil (3.46 g), Rf. 0.5 (SS2). δ(CDCl3): 1.44(9H,s), 2.37(3H,s), 2.77(2H,t), 2.87(2H,t), 3.23(2H,m), 3.68(3H,s), 4.28(2H,s), 4.45(2H,t), 4.53(1H,br), 6.82(1H,d), 7.10-7.13(2H,m), 7.21(1H,d), 7.29(1H,d), 8.38-8.42(2H,m).

Provenance & Evidence