Potassium Cyanide → 2-Amino-2-(6-methylpyridin-3-yl)acetonitrile

Participants

Reaction Steps

To a solution of potassium cyanide (6.96 g, 107 mmol) and ammonium chloride(5.72 g, 107 mmol) in water (5 ml) was added 6-methyl-3-pyridin-carboxaldehyde (8.68 g, 71.5 mmol) and the reaction mixture was stirred at room temperature for 18 h. The reaction mixture wasbasified with 50% NaOH and extracted with ethyl acetate. The organic phase was dried (MgSO4) and evaporated to give the crude desired product in7 g yield. The product was used without further purification.

Provenance & Evidence