Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1-Azabicyclo(2.2.2)octan-3-one, hydrochloride (1:1) | HCID 102019 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-Quinuclidinone | HCID 19507 | — |
Reaction Steps
300 g (1.856 mol) of 3-quinuclidinone hydrochloride (Fluka) was added at 40° C. to a solution of 300 g (7.50 mol) of sodium hydroxide in 1 liter of water and the solution formed was cooled to 20° C. It was then extracted three times with 400 ml of ethyl acetate and the combined organic extracts were dried over magnesium sulfate. After evaporation, 220g (95 percent) of 3-quinuclidinone was obtained in the form of a light beige solid. Other data concerning the product was: ##EQU1##
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05744606 |
|---|
| Source dataset | uspto-grants-1998_04 |
|---|
| ORD ID | ord-ea5766e25131423faa117e11ddd126fc |
|---|
| Source note | uspto-grants-1998_04 |
|---|
