HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Hydroxymethyl)-1H-benzimidazole → 1H-Benzimidazole-2-carboxaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Hydroxymethyl)-1H-benzimidazole | HCID 78569 | — |
| Catalyst | Manganese dioxide | HCID 14801 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1H-Benzimidazole-2-carboxaldehyde | HCID 76826 | — |
Reaction Steps
A mixture of 2-Hydroxymethyl-benzimidazole (11.9 g) and MnO2 (59.5 g in ethanol (250 mL) was vigorously stirred for 2 days. The reaction was concentrated in vacuo, hot dimethylformamide was added and the mixture wasfiltered through celite. After removal of the solvent in vacuo the tan solid was triturated with ethanol to afford 2-Benzimidazolecarboxaldehyde as a tan powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05744603 |
| Source dataset | uspto-grants-1998_04 |
| ORD ID | ord-577612f0378c4d57814c0c1dd2f0cc6e |
| Source note | uspto-grants-1998_04 |