反应详情

Into the same device as used in Example 34 were placed 43.5 g (0.10 mole) of ethyl ester of 1-(2'-cyanobiphenyl-4-yl)methyl-4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylic acid, 13.1 g (0.20 mole) of sodium azide, 31.9 g (0.23 mole) of triethylamine hydrochloride and 206 ml of toluene. Thereafter, the mixture was reacted and treated in the same manner as in Example 34, giving 27.0 g (0.06 mole) of 4-(1-hydroxy-1-methylethyl)-2-propyl-1-{4-[2-(tetrazole-5-yl)phenyl]phenyl}methylimidazole-5-carboxylic acid (yield 60.0% based on ethyl ester of 1-(2'-cyanobiphenyl-4-yl)methyl-4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylic acid).

1. customThereafter, the mixture was reacted
2. additiontreated in the same manner as in Example 34