HCID 178418332, compound → HCID 178418336, compound

HRID 1600387Notes

Reaction equation

HRID 1600387 reaction equation
[C:1]1([Mg]Cl)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C1(C[CH2:16][Mg:17][Cl:18])C=CC=CC=1.C1(CC[Mg]Br)C=CC=CC=1.C1(CCC[Mg]Br)C=CC=CC=1.C[Mg]Cl>>[CH2:16]([Mg:17][Cl:18])[C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

6

Reactant 5

HCID 178418332HCID 178418332, compoundHCID 178418471HCID 178418471, compoundHCID 178418865HCID 178418865, compoundHCID 178419670HCID 178419670, compoundHCID 178478979HCID 178478979, compound

Product 1

HCID 178418336HCID 178418336, compound

Procedure

The same procedures as described In Preparation Example 1 were repeated using phenyl magnesium chloride, 2-phenylethyl magnesium chloride, 2-phenylethyl magnesium bromide, 3-phenylpropyl magnesium bromide and methyl magnesium chloride, respectively, in place of benzyl magnesium chloride to obtain functionalized amines. Each compound obtained in Preparation Examples 4 to 7 and physical properties thereof are given below in table 4.

Workup

  1. customThe same procedures as described In Preparation Example 1

Sources & evidence

ORD record
ord-99348a212c094940b633bb6424317f5c
Source dataset
uspto-grants-1998_04
Patent number
US05744621

Reaction notes

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