HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-2-nitrophenol → 2-Amino-4-chlorophenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-2-nitrophenol | HCID 6980 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Phosphine | HCID 24404 | — |
| Reactant | Trisodium 3,3',3''-phosphinetriyltris(benzene-1-sulphonate) | HCID 6099338 | — |
| Catalyst | Palladium Chloride | HCID 24290 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | 2-Amino-4-chlorophenol | HCID 7265 | — |
Reaction Steps
A degassed solution of 10 mmol of 5-chloro-2-hydroxynitrobenzene (starting material) and 40 ml of xylene are placed in an autoclave (volume: 200 ml).0.25 mmol of TPPTS (in the form of 4.6 g of an aqueous solution containing 0.546 mol of TPPTS/kg of solution) as phosphine and 0.6 g (15 mmol) of NaOH, 41 ml of H2O and 0.25 mmol of PdCl2 are added. The pH is from 10 to 10.5.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05744643 |
| Source dataset | uspto-grants-1998_04 |
| ORD ID | ord-43d247b102ec4fe68a2033feee667dff |
| Source note | uspto-grants-1998_04 |