Guanidine → HCID 18927266, compound

Participants

Reaction Steps

A suspension of 1 g of N-diaminomethylene-2-methyl-4-chloro-5-methylsulfonylbenzamide [obtainableby reaction of 2-methyl-4-chloro-5-methylsulfonylbenzoyl chloride with guanidine in the presence of triethylamine], 7 ml of thiophenol and 6 g ofK2CO3 is heated at 180° for 90 min. It is dissolved in water and extracted with ethyl acetate, and the extract is evaporated. N-Diaminomethylene-2-methyl-4-(2-methylphenylthio)-5-methylsulfonylbenzamide is obtained, from which, after treatment with 1.5 g of sodium perborate in 30 ml of glacial acetic acid over a period of 2 hours at 60° C. in a water bath, N-diaminomethylene-2-methyl-4-(2-methylphenylsulfonyl)-5methylsulfonylbenzamide is obtained after customary working up.

Provenance & Evidence