Fumarate → 5-Methyl-2-(1-methyl-1,2,5,6-tetrahydro-3-pyridyl)-thiazole

HRID 1600453Notes

Reaction equation

HRID 1600453 reaction equation
[CH3:1][C:2]1[S:6][C:5]([C:7]2[CH:8]=[N:9][CH:10]=[CH:11][CH:12]=2)=[N:4][CH:3]=1.[C:13]([O-])(=O)/C=C/C([O-])=O>>[CH3:1][C:2]1[S:6][C:5]([C:7]2[CH2:8][N:9]([CH3:13])[CH2:10][CH2:11][CH:12]=2)=[N:4][CH:3]=1

Participants

3

Reactant 2

HCID 5460307FumarateHCID 196125135-Methyl-2-(3-pyridyl)-thiazole

Product 1

HCID 196124795-Methyl-2-(1-methyl-1,2,5,6-tetrahydro-3-pyridyl)-thiazole

Procedure

The title compound was prepared from 88 (2.2 g, 0.013 mol) by the procedure described in Example 49. The crude free base obtained, 89, was converted to the title fumarate, 90. Yield: 0.8 g (0.0032 mol, 25%). M.P. 159°-160° C. Anal. (C12H16N2O2S)C, H, N.

Workup

  1. customThe crude free base obtained

Sources & evidence

ORD record
ord-1f3d63b3d76045508493ba53e1f22655
Source dataset
uspto-grants-1999_11
Patent number
USRE036374

Reaction notes

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