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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1600530Generated: October 28, 2026

Formaldehyde → benzyl 2-(N-methyleneamino)-2-methylpropanoate

https://huagongshe.com/reaction/1600530

Reaction equation

Participants

RoleNameHCIDCharge
ReactantFormaldehydeHCID 712—
ReactantBenzyl 2-amino-2-methylbutyrateHCID 21829894—
SolventDiethyl EtherHCID 3283—
Productbenzyl 2-(N-methyleneamino)-2-methylpropanoateHCID 19354575106.7%

Reaction Steps

To benzyl 2-amino-2-methylbutyrate (12.96 g) was dropped at room temperature 37% formalin (7.62 g), and the mixture was stirred for 4 h. The reaction mixture was dissolved in ether and washed with water. The organic phase was dried over magnesium sulfate, filtered and evaporated to get the captioned compound (13.7 g).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05977025
Source datasetuspto-grants-1999_11
ORD IDord-670e81ef862144a281e4a9bd8d1a1375
Source noteuspto-grants-1999_11