Benzene, (2-bromoethoxy)- → tert-butyl (1RS,2RS,3RS,5SR)-2-(naphthalen-2-ylmethoxy)-3-[4-(2-phenoxy-ethoxymethyl)-phenyl]-8-aza-bicyclo[3.2.1]octane-8-carboxylate

HRID 160063Notes

Reaction equation

HRID 160063 reaction equation
[O:36]([c:37]1[cH:38][cH:39][cH:40][cH:41][cH:42]1)[CH2:43][CH2:44][Br:45].[OH:1][CH2:2][c:3]1[cH:4][cH:5][c:6]([CH:9]2[CH:10]([O:24][CH2:25][c:26]3[cH:27][c:28]4[cH:29][cH:30][cH:31][cH:32][c:33]4[cH:34][cH:35]3)[CH:11]3[CH2:12][CH2:13][CH:14]([CH2:15]2)[N:16]3[C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23])[cH:7][cH:8]1>>[O:1]([CH2:2][c:3]1[cH:4][cH:5][c:6]([CH:9]2[CH:10]([O:24][CH2:25][c:26]3[cH:27][c:28]4[cH:29][cH:30][cH:31][cH:32][c:33]4[cH:34][cH:35]3)[CH:11]3[CH2:12][CH2:13][CH:14]([CH2:15]2)[N:16]3[C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23])[cH:7][cH:8]1)[CH2:44][CH2:43][O:36][c:37]1[cH:38][cH:39][cH:40][cH:41][cH:42]1

Participants

3

Reactant 2

HCID 68526Benzene, (2-bromoethoxy)-HCID 70131603tert-butyl (1RS,2RS,3RS,5SR)-3-(4-hydroxymethyl-phenyl)-2-(naphthalen-2-ylmethoxy)-8-aza-bicyclo[3.2.1]octane-8-carboxylate

Product 1

HCID 86604518tert-butyl (1RS,2RS,3RS,5SR)-2-(naphthalen-2-ylmethoxy)-3-[4-(2-phenoxy-ethoxymethyl)-phenyl]-8-aza-bicyclo[3.2.1]octane-8-carboxylate

Sources & evidence

ORD record
ord-01ceba7c2f954b8bb492dbc1c476ce33
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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