Methyl iodide → HCID 9803683, compound

Participants

Reaction Steps

The compound 1 (3.77 g; 0.009 mol is added dropwise to a 60% suspension of sodium hydride in paraffin oil (0.77 g; 0.019 mol) in DMF (50 ml), followed, after stirring for 2 hours at room temperature, by iodomethane (1.4 g; 0.01 mol). After leaving overnight at room temperature, the mixture is concentrated to dryness under vacuum and then the residue is taken up in water (100 ml) and extracted with ethyl ether (2×50 ml). The dried organic phases (Na2SO4) are concentrated to dryness under vacuum to give an oil which crystallizes slowly.

Provenance & Evidence