3-Chloro-4-fluoroaniline → HCID 21830556, compound

HRID 1600674Notes

Reaction equation

HRID 1600674 reaction equation
Cl[C:2]1[C:3]2[N:11]=[C:10]([S:12][CH3:13])[N:9]=[CH:8][C:4]=2[N:5]=[CH:6][N:7]=1.[Cl:14][C:15]1[CH:16]=[C:17]([CH:19]=[CH:20][C:21]=1[F:22])[NH2:18]>O1CCOCC1>[Cl:14][C:15]1[CH:16]=[C:17]([NH:18][C:2]2[C:3]3[N:11]=[C:10]([S:12][CH3:13])[N:9]=[CH:8][C:4]=3[N:5]=[CH:6][N:7]=2)[CH:19]=[CH:20][C:21]=1[F:22]

Participants

4

Reactant 2

HCID 97083-Chloro-4-fluoroanilineHCID 152952158-Chloro-2-(methylsulfanyl)pyrimido[5,4-d]pyrimidine

Product 1

HCID 21830556HCID 21830556, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

3.0 g of 4-chloro-6-methylthiopyrimido[5,4-d]pyrimidine, 3.8 g of 3-chloro-4-fluoroaniline and 10 ml of dioxane are heated at 80° C. for 2 hours. After cooling, the reaction mixture is concentrated and triturated first with water and then with diethyl ether, filtered off with suction and dried.

Workup

  1. temperatureAfter cooling
  2. concentrationthe reaction mixture is concentrated
  3. customtriturated first with water
  4. filtrationwith diethyl ether, filtered off with suction
  5. customdried

Sources & evidence

ORD record
ord-be75bdb185a541c3bf4eb814b94c37ec
Source dataset
uspto-grants-1999_11
Patent number
US05977102

Reaction notes

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