Carbon tetrabromide → HCID 178419550, compound

Participants

Reaction Steps

A mixture of trans-2-[4-(pyrimidin-2-ylamino)-cyclohexyl]-ethanol (1.51 g, 6.9 mmol) is dissolved in a solution of methylene chloride (25 mL) containing polymer supported triphenylphosphine (2.87 g, approx 8.6 mmol). The mixture is cooled in an ice water bath, and carbon tetrabromide (2.3 g, 7.0 mmol) is added. The reaction is stirred for 1 hour, and the polymeric material was removed by filtration. The filtrate is concentrated and chromatographed on silica gel using a 2:1 mixture of chloroform and ethyl acetate (EtOAc) as the solvent to give trans-[4-(2-Bromoethyl)-cyclohexyl]-pyrimidin-2-yl-amine.

Provenance & Evidence