HCID 178418361, compound → HCID 178512490, compound

Participants

Reaction Steps

Trans-N-{4-[2-(4-phenyl-piperazin-1-yl)-ethyl]cyclohexyl-N,N'-dicarbobenzyloxyguanidine (2.77 g, 4.63 mol) was hydrogenolyzed in MeOH (250 mL) under 48 psi hydrogen pressure in the presence of 20% palladium on carbon catalyst (0.25 g). Filtration of the reaction mixture, evaporation of the filtrate, and recrystallization of the residue from isopropanol (i-PrOH)-Et2O yielded 1.39 g (91%) of the product; mp 140-170° C.

Provenance & Evidence