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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1600689Generated: October 26, 2026

5-(Piperazin-1-yl)benzofuran-2-carboxamide → Vilazodone

https://huagongshe.com/reaction/1600689

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-(Piperazin-1-yl)benzofuran-2-carboxamideHCID 9834719—
Reactant3-(4-Chlorobutyl)-5-cyanoindoleHCID 9881123—
ProductVilazodoneHCID 6918314—

Reaction Steps

5-(1-piperazinyl)benzofuran-2-carboxamide or a corresponding salt is reacted with 3-(4-chlorobutyl)-5-cyanoindole to give 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoylbenzofuran-5-yl)piperazine and optionally then converted into its acid addition salt.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05977112
Source datasetuspto-grants-1999_11
ORD IDord-a4b36d73ae5647198f1d95cbd55f4e83
Source noteuspto-grants-1999_11