HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Benzofurancarboxylic acid, 5-nitro-, ethyl ester → Ethyl 5-aminobenzofuran-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Benzofurancarboxylic acid, 5-nitro-, ethyl ester | HCID 1382954 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Ethyl 5-aminobenzofuran-2-carboxylate | HCID 9837138 | — |
Reaction Steps
A solution of 2.3 g of ethyl 5-nitrobenzofuran-2-carboxylate in 60 ml of methanol is hydrogenated in the presence of Raney nickel. The catalyst is filtered off and the solution is concentrated. After customary working up, ethyl 5-aminobenzofuran-2-carboxylate, Rf 0.1 (dichloromethane/ethanol 9.5:0.5) is obtained; hydrochloride m.p. 246-248°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05977112 |
| Source dataset | uspto-grants-1999_11 |
| ORD ID | ord-490c8e3ba36b4061b398ea79c6055a70 |
| Source note | uspto-grants-1999_11 |