HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formamide → Tert-butyl 4-(2-carbamoylbenzofuran-5-yl)piperazine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formamide | HCID 713 | — |
| Reactant | 1-Piperazinecarboxylic acid, 4-[2-(ethoxycarbonyl)-5-benzofuranyl]-, 1,1-dimethylethyl ester | HCID 11176275 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | Tert-butyl 4-(2-carbamoylbenzofuran-5-yl)piperazine-1-carboxylate | HCID 11244883 | — |
Reaction Steps
A solution of 3 g of ethyl 5-(4-tert-butoxycarbonyl-1-piperazinyl)benzofuran-2-carboxylate in 100 ml of N-methylpyrrolidone is stirred for 5 hours with 1 g of formamide and 3 g of sodium alkoxide. After customary working up, 5-(4-tert-butoxycarbonyl-1-piperazinyl)benzofuran-2-carboxamide, m.p. 198-200°, is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05977112 |
| Source dataset | uspto-grants-1999_11 |
| ORD ID | ord-13f3e0e44c3c4141a37655c9981121d3 |
| Source note | uspto-grants-1999_11 |