Nitric Acid → HCID 10542584, compound

HRID 1600705Notes

Reaction equation

HRID 1600705 reaction equation
[Cl:1][C:2]1[C:3]([F:16])=[C:4]([NH:9][C:10](=[O:15])[C:11]([F:14])([F:13])[F:12])[CH:5]=[CH:6][C:7]=1[F:8].[N+:17]([O-])([OH:19])=[O:18]>OS(O)(=O)=O>[Cl:1][C:2]1[C:3]([F:16])=[C:4]([NH:9][C:10](=[O:15])[C:11]([F:12])([F:13])[F:14])[C:5]([N+:17]([O-:19])=[O:18])=[CH:6][C:7]=1[F:8]

Participants

4

Reactant 2

HCID 944Nitric Acid2×HCID 104915413-Chloro-2,4-difluoro-(trifluoroacetamido)benzene

Product 1

HCID 10542584HCID 10542584, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

To a solution of 15.1 g (58.1 mmol) of 3-chloro-2,4-difluoro-(trifluoroacetamido)benzene in 80 mL of H2SO4 kept in an ice-bath was added dropwise 10 mL of HNO3. Solid precipitate was observed during addition of HNO3. The mixture was stirred in an ice-bath for 4 h, then added to 600 mL of ice-water. The precipitate was filtered, washed with water, and dried to leave an almost colorless solid (16.8 g, 95%); mp 124-125° C.; 1H NMR (CDCl3), 7.69 (dd, 1), 8.936 (mb, 1).

Workup

  1. filtrationThe precipitate was filtered
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-3e5e0564e0d74ac293cf95d267d45f00
Source dataset
uspto-grants-1999_11
Patent number
US05977107

Reaction notes

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