HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(2-Chlorophenyl)-4-cyanopiperidine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 4-(2-chlorophenyl)-4-cyanopiperidine-1-carboxylate | HCID 21712251 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4-(2-Chlorophenyl)-4-cyanopiperidine hydrochloride | HCID 22379274 | — |
Reaction Steps
A solution of EtOAc saturated with HCl (200 ml) was added to 4-(2-chlorophenyl)-4-cyano-N-(1,1-dimethylethoxycarbonyl)piperidine, (880 mg, 2.74 mmol). The resulting mixture was allowed to react for 1 hour at room temperature. The EtOAc was removed in vacuo affording 4-(2-Chlorophenyl)-4-cyanopiperidine hydrochloride as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05977115 |
| Source dataset | uspto-grants-1999_11 |
| ORD ID | ord-ddfc09c87fc4446b92d6a7c31ebb57a7 |
| Source note | uspto-grants-1999_11 |