HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → HCID 178437885, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | 1H-Benzimidazole-1-acetic acid, ethyl ester | HCID 171417 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | 5-amino-1-cyclopentyl-3-ethyl-1H-pyrazole-4-carboxamide | HCID 22449352 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 178437885 | HCID 178437885 | 75% |
Reaction Steps
Sodium (338 mg) was dissolved in ethanol (30 mL) and 1-(ethoxycarbonylmethyl)benzimidazole (3.0 g, 14.7 mmol) and 1-cyclopentyl-3-ethyl-5-amino-1H-pyrazole-4-carboxamide (1.6 g) were added. The reaction mixture was refluxed overnight, the solvent was stripped and the residue was treated with water and acetic acid. A precipitate formed which was collected by filtration and washed with water to afford 1.96 g (75%) of 1-cyclopentyl-3-ethyl-6-[1-benzimidazolylmethyl]pyrazolo-[3,4-d]pyrimidin-4-one, m.p. 256-259° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05977118 |
| Source dataset | uspto-grants-1999_11 |
| ORD ID | ord-e7ce6c629daa42dcb4afd3ba2039039d |
| Source note | uspto-grants-1999_11 |