Hydrogen Peroxide → HCID 21830878, compound

Participants

Reaction Steps

To a mixture of water (200 mL), ethanol (120 mL) and KOH (37 g, 0.56 mol) at 0° C. was added 30% H2O2 (89.1 g, 0.786 mol), followed by 1-tert-butyl-3-methyl-5-amino-1H-pyrazole-4-carbonitrile (20.0 g, 0.112 mol). The reaction mixture was stirred for 4 hours and the product was collected by filtration, washed with water and dried to afford 20.64 g (94%) of 1-tert-butyl-3-methyl-5-amino-1H-pyrazole-4-carboxamide, as white needles, m.p. 195-196° C.

Provenance & Evidence