Lithium hydroxide, monohydrate → HCID 54348024, compound

Participants

Reaction Steps

To a solution of N-benzyloxycarbonyl-L-valyl-4-(phenylcarbonylamino)-L-phenylalanine methyl ester (0.500 g, 0.94 mmol) in dioxane (30 ml) is added lithium hydroxide monohydrate (0.084 g, 2 mmol) in water (10 ml). The reaction is stirred at room temperature overnight. The mixture is taken off in water (20 ml) and washed twice with ethyl acetate (2×20 ml). The aqueous phase is acidified until pH ~2 with 1N hydrochloric acid and extracted three times with ethyl acetate (3×20 ml). The organic layer is dried over anhydrous magnesium sulphate. After filtration and remtial of the solvent invacuo the title compound is obtained as a white solid (0.400 g, 82% yield). MS: [MH]+ =518 [MNH4 ]+ =535.

Provenance & Evidence