HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1600871Generated: October 30, 2026
Triphenylphosphine → HCID 21830927, compound
https://huagongshe.com/reaction/1600871
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 3-(3-Cyclopentyloxy-4-methoxyphenyl)-3-ethynylcyclohexan-1-one | HCID 15392007 | — |
| Reactant | 2,2,2-Trifluoro-N-(3-iodophenyl)acetamide | HCID 18877657 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 21830927 | HCID 21830927 | 78% |
Reaction Steps
To a solution of the compound from Example 3 (E1) (0.5 g. 1.6 mmol) and 1-iodo-3-trifluoroacetamidobenzene (0.5 g, 1.6 mmol) in triethylamine (10 mL) under an argon atmosphere was added a small amount of tetrakis(triphenylphosphine)palladium(0), copper(I) iodide and triphenylphosphine. The mixture was heated at 80° C. for 0.2 h, was cooled to room temperature and was concentrated in vacuo. The residue was purified by flash chromatography, eluting with 3:1 hexanes/ethyl acetate, to give the title compound as a pale yellow solid (0.62 g, 78%), m.p. 63-65° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05977122 |
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| Source dataset | uspto-grants-1999_11 |
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| ORD ID | ord-3afee063fef04e6d8c87a5ebe5324df3 |
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| Source note | uspto-grants-1999_11 |
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