反应详情

温度

20 °C

A solution of 14.4 g (45.3 mmol) of methyl 2-[2-(tetrahydropyran-2-yloxy)-phenyl]-3-cyanomethoxy-acrylate in 50 ml of methanol is admixed with 5 g of acidic ion exchanger and stirred at 20° C. for 3 hours. The ion exchanger is filtered off and the filtrate is concentrated under reduced pressure. The residue is chromatographed over silica gel using dichloromethane/ethyl acetate (10:1). 7.8 g (74% of theory) of methyl 2-(2-hydroxyphenyl)-3-cyanomethoxy-acrylate are obtained.

1. filtrationThe ion exchanger is filtered off
2. concentrationthe filtrate is concentrated under reduced pressure
3. customThe residue is chromatographed over silica gel