2-Naphthalenethiol → HCID 21830630, compound

HRID 1600893Notes

Reaction equation

HRID 1600893 reaction equation
[CH:1]1[CH:10]=[C:9]2[C:4]([CH:5]=[C:6]([SH:11])[CH:7]=[CH:8]2)=[CH:3][CH:2]=1.[N:12]1[CH:17]=[CH:16][CH:15]=[C:14]([CH2:18][CH2:19][C:20](=[O:23])[CH:21]=[CH2:22])[CH:13]=1>C(O)C>[N:12]1[CH:17]=[CH:16][CH:15]=[C:14]([CH2:18][CH2:19][C:20](=[O:23])[CH2:21][CH2:22][S:11][C:6]2[CH:7]=[CH:8][C:9]3[C:4](=[CH:3][CH:2]=[CH:1][CH:10]=3)[CH:5]=2)[CH:13]=1

Participants

4

Reactant 2

HCID 70582-NaphthalenethiolHCID 218306261-(3-Pyridyl)-4-penten-3-one

Product 1

HCID 21830630HCID 21830630, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-Thionaphthol was added to a solution of 1-(3-pyridyl)-4-penten-3-one (0.200 g) in ethanol (30 ml) followed by stirring overnight at room temperature. The ethanol was removed under reduced pressure and the residue purified by column chromatography over silica eluting with dichloromethane:ethyl acetate (2:1) to give the sub-title compound as a white solid (0.142 g).

Workup

  1. customThe ethanol was removed under reduced pressure
  2. customthe residue purified by column chromatography over silica eluting with dichloromethane:ethyl acetate (2:1)

Sources & evidence

ORD record
ord-59a8a781c3df46478763d2b69215da3e
Source dataset
uspto-grants-1999_11
Patent number
US05977105

Reaction notes

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