HuagongsheHuagongshe Chemistry Print Report · For research reference only
4,4'-Dihydroxydiphenyl ether → (+/-)-alpha-(4-(4-Hydroxyphenoxy)phenoxymethyl)-3-pyridinepropanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4,4'-Dihydroxydiphenyl ether | HCID 16069 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | HCID 10877288 | HCID 10877288 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (+/-)-alpha-(4-(4-Hydroxyphenoxy)phenoxymethyl)-3-pyridinepropanol | HCID 21830679 | 14% |
Reaction Steps
Prepared according to the method described in Example 5 from 4,4'-dihydroxydiphenyl ether (1.68 g), (±)-3-(2-oxiranylethyl)pyridine (1.24 g) and sodium hydride (60% dispersion in oil; 0.319 g) in dimethylformamide (20 ml) at 100° C. for 2 hours to give the title compound as a white solid (0.41 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05977105 |
| Source dataset | uspto-grants-1999_11 |
| ORD ID | ord-cf4e03c9b79a465d8c6b4ca41e05df51 |
| Source note | uspto-grants-1999_11 |