Sodium borohydride → HCID 21830627, compound

HRID 1600901Notes

Reaction equation

HRID 1600901 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][C:16](=[O:25])[CH2:17][CH2:18][C:19]3[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=3)=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[BH4-].[Na+]>C(O)C>[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][CH:16]([OH:25])[CH2:17][CH2:18][C:19]3[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=3)=[CH:10][CH:9]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 21830739HCID 21830739, compound

Product 1

HCID 21830627HCID 21830627, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Prepared according to the method described in Example 7c) from 1-(4'-hydroxybiphenyl-4-yl)-5-(3-pyridyl)-3-pentanone (0.52 g) and sodium borohydride (0.062 g) in ethanol (10 ml) to give a yellow gum, which was purified by column chromatography over silica eluting with ethanol:ethyl acetate (1:9) to give the title compound as a yellow gum that solidified on standing (0.39 g).

Workup

  1. customPrepared
  2. customto give a yellow gum, which
  3. customwas purified by column chromatography over silica eluting with ethanol:ethyl acetate (1:9)

Sources & evidence

ORD record
ord-427b5a619ad64814860c20d245427bbe
Source dataset
uspto-grants-1999_11
Patent number
US05977105

Reaction notes

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