Sodium borohydride → HCID 21830758, compound

Participants

Reaction Conditions

Reaction Steps

1-{6-(Methoxymethoxy)-2-naphthyl}-5-(3-pyridyl)-3-pentanone (1.9 g; from Example 31 above) was immediately dissolved in methanol (100 ml) and cooled to 0° C. Solid sodium borohydride (0.284 g) was added and the reaction mixture stirred at 25° C. for 2 hours. The mixture was concentrated under reduced pressure and water was added to the residue. The aqueous mixture was extracted with ethyl acetate. The combined extracts were dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The residue was purified by column chromatography over silica eluting with dichloromethane:methanol (95:5) to give an oil (0.94 g).

Provenance & Evidence