反应详情

A solution of (±)-α-(chloromethyl)-3-pyridinepropanol (0.80 g) in ethanol (10 ml) was added to a refluxing solution of 3'-nitrobiphenyl-4-ol (1.40 g) in ethanol (20 ml) and aqueous sodium hydroxide (1.4 M, 5 ml) over 30 minutes. The solution was heated at reflux for a further hour and then was cooled to room temperature. The reaction mixture was concentrated under reduced pressure and the residue purified by column chromatography over silica eluting with chloroform:ethanol (49:1 to 24:1) to give a yellow solid after trituration with ether (0.332 g).

1. temperatureThe solution was heated
2. temperatureat reflux for a further hour
3. concentrationThe reaction mixture was concentrated under reduced pressure
4. customthe residue purified by column chromatography over silica eluting with chloroform:ethanol (49:1 to 24:1)
5. customto give a yellow solid after trituration with ether (0.332 g)