Imidazole → HCID 21717163, compound

Participants

Reaction Steps

Imidazole (0.73 g) and dimethylaminopyridine (10 mg) was added to a solution of (±)-1-(4-bromophenoxy)-4-(3-pyridyl)-2-butanol (2.20 g) in dimethylformamide (15 ml). When the mixture was homogeneous solid tert-butyldimethylsilyl chloride was added and the solution stirred for 26 hours. A saturated aqueous solution of sodium chloride (200 ml) was added and the mixture extracted with ether (3×100 ml). The combined organic extracts were dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give the sub-title compound as an oil (2.75 g).

Provenance & Evidence